McHardy Group/CIDD Publications

“A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by a de novo crystal structural and spectroscopic study”. Shin, I., Davis, I., Nieves-Merced, K., Wang, Y., McHardy, S.F., Liu, A. Chemical Science, (2021), ahead of print.

 

“Modulation of a α1β3γ2 GABAA receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix”. Borghese, C.M., Messing, R.O., Harris, R.A., Wang, H.L., McHardy, S.F., Trudell, J.R., Bertaccini, E.J. Proceedings of the National Academy of Sciences of the United States of America, 2021118(8).  

 

“Diabetic strips as coulometric sensors for hydroquinone and leukocyte esterase”. Bekhit, M., Wang, H-Y., Menard, T., McHardy, S.F., Gorski, W. J. Electroanal. Chem, 2020874: 114509.

 

“Infection screening in biofluids with glucose test strips”. Bekhit, M., Wang, H-Y., McHardy, S.F., Gorski, W. Anal. Chem., 202092, 3860-3866. PMID32040916. 

 

“Molecular basis for hycanthone drug action in schistosome parasites”. Rugel, A.R., Guzman, M.A., Taylor, A.B., Chevalier, F.D., Anderson, T.J.C., Tarpley, R.S., McHardy, S.F., Cao, X., Holloway, S.P., Hart, P.J., LoVerde, P.T. Mol. Biochem. Parasitol., 2020236, 111257. PMID32027942. 

 

“Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum”. Rugel, A.R., Guzman, M.A., Taylor, A.B., Chevalier, F.D., Anderson, T.J.C., Tarpley, R.S., McHardy, S.F., Cao, X., Holloway, S.P., Hart, P.J., LoVerde, P.T. Int. J. Parasitol. Drugs Drug Resistance202013, 8-15. PMID32315953.

 

“An iterative process produces oxamniquine derivatives that kill the major human species of schismtosomes”. Guzman, M.A., Rugel, A.R., Tarpley, R.S., Alwan, S.N., Chevalier, F.D., Kovalsky, D.P., Cao, X., Holloway, S.P., Anderson, T.J.C., Taylor, A.B., McHardy, S.F., LoVerde, P.T. PLOS Neglected Trop. Dis., 202014(8): e0008517. PMID32810153.

 

 “Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis”. Selyunin, A.S., Hutchens, S., Mukhopadhyay, S., McHardy, S.F. Life Science Alliance20192, 3. PMID31243048. 

 

“The novel capsazepine analog, CIDD-99, significantly inhibits oral aquamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction and apoptosis”. De La Chapa, J., Singha, P., Self, K., Sallaway, M., McHardy, S.F., Hart, M., McGuff, H.S., Valdez, M., Ruiz, F. III., Gonzales, K., Mitchell, W., Srikanth, R., Polusani, S.R., Gonzales, C.B. J. Oral Pathol. Med, 201948, 389-399. PMID30825343.

 

“Small molecule nicotinamide N-methyltransferase inhibitors activate senescent muscle stem cells and improve regenerative capacity of aged skeletal muscle”.  Watowich, S., Neelakantan, H., Brightwell, C.R., Graber, T. G., Maroto, R., Wang, H.L., McHardy, S.F., Papaconstantinou, J., Fry, C.F. Biochemical Pharmacology2019163, 481-492. PMID30753815.

 

“A modular PROTAC design for target destruction using a degradation signal based on a single amino acid”. Shanmugasundaram, K., Shao, P., Chen, H., Campos, B., McHardy, S.F., Luo, T., Rao, H. J. Biol. Chem.2019, 294, 15172-15173. PMID31511327.

 

“Structure activity relationships for capsazepine analogs that induce mitochondrial dysfunction and S-phase accumulation in OSCC”. Self, K., De La Chapa, J.J., Valdez, M., Ruiz III, F., Mitchell, W., McHardy, S.F., Hart, M., Gonzales, C.B. Bioorganic & Medicinal Chemistry201927, 208-215.

 

“Design, synthesis, and characterization of novel small molecules as broad range anti-schistosomal agents”. Stahl, S., Tarpley, R., Lopez, A., Menard, T., Guzman, M.A., Taylor, A.B., Cao, X., Chevalier, F.D., Anderson, T.J.C., Hart, J., LoVerde, P.T., McHardy, S.F. ACS Med. Chem. Letters, 20189, 967-973 (Editor selected as featured letter and highlighted on the journal cover).

 

“Synthesis and characterization of pyridine compounds for amperometric measurements of leukocyte esterase”. Hanson, D., Menard, T., Shoemake, T., McHardy, S.F., Gorski, W. Chembiochem, 201819, 1488-1491.

 

“Selective and membrane-permeable small molecule inhibitor of nicotinamide N-methyltransferase reverses high fat diet-induced obesity in mice”. Neelakantan, H., Vance, V., Wetzel, M., Wang, H.L., McHardy, S.F., Finnerty, C., Hommel, J.D., Watowich, S.J. Biochemical Pharmacology, 2018, 147, 141-152.

 

“Novel small molecule inhibitors of protein kinase C Epsilon reduce ethanol consumption in mice”. Blasio, A., Wang, D., Wang, J., Varodayan, F.P., Miller, J., Lee, A.M., McMahon, T., Pomrenze, M.B., Gyawali, S., Wang, H., Roberto, M., McHardy, S.F., Pleiss, M.A., Messing, R.O. Biological Psychiatry201884, 193-201.

 

“Development of anti-virulence approaches for Candidiasis via a novel series of small-molecule inhibitors of Candida albicans filamentation”. Romo,  J.A., Chaturvedi,  A.K., Lazzell, A.L., Saville, S.P., Lopez-Ribot, J.L., Pierce,  C.G., McHardy, S.F. mBio2017, 8(6).

 

“Structure activity relationship studies of new cytotoxic oxazoles with selectivity for androgen receptor-positive breast cancer cells”. Robles, A.J.,  McCowen, S., Cai, S., Cichewicz, R.H., Mooberry, S.L., McHardy, S.F.  J. Med. Chem.201760, 9275-9289.

 

“Electrochemical substrate and assay for esterolytic activity of human white blood cells”. Hanson, D., Menard, T., McHardy, S.F., Fleischman, A., Gorski, W. Analytical Chemistry201789, 7781-7787.

 

“Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy”. Taylor, A.B., Cao, X., Clark, N., Holloway, S.P., LoVerde, P.T.,  Fitzpatrick, P.F., Hart, J.P., Roberts, K.M., Donati, E., Polcaro, C.M., Pica-Mattoccia, L., Cioli, D., Tarpley, R.S., McHardy, S.F. J. Biol. Chem.2017292, 11154-11164. (Paper highlighted on journal cover)

 

“Structure-activity relationship for Small molecule inhibitors of nicotinamide N-methyltransferase”. Neelakantan, H., Wang, H., Vance, V., Hommel, J.D., McHardy, S.F., Watowich, S.J. J. Med. Chem., 201760, 5015-5028.

 

“Noncoupled fluorescent assay for direct real-time monitoring of nicotinamide N-methyltransferase activity”. Neelakantan, H., Vance, V., Wang, H., McHardy, S.F., Watowich, S.J. Biochemistry201756, 824-832.

 

“Targeting Candida albicans filamentation for antifungal drug development”. Vila, T., Romo, J.A., Saville, S.P., Lopez-Ribot, J.L., Pierce, C.G., McHardy, S.F. Virulence20178, 150-158.

 

“Recent advances in acetylcholinesterase inhibitors and reactivators: an update on the patent literature (2012-2015)”. McHardy, S.F., Wang, H., McCowen, S., Valdez, M. Expert Opinion On Therapeutic Patents2016, 1354-3776.

 

“Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer”.  Long Cheng, B.Y., Ye, Q., Gupta, K., Chiang, H., Hu,  Y., Li, R., Gupta, H.B., Lathrop, K., Elledge, R., Curiel, T.J., Sareddy, G.R., Vadlamudi, R., Wang,  D., Wang , P., McHardy, S.F. Oncotarget, 2016, 42585-42597.

 

“Targeting Candida albicans filamentation for antifungal drug development”. Vila, T., Romo, J.A., Saville, S.P.,  Lopez-Ribot, J.L., Pierce, C.G., McHardy, S.F. Virulence, 2016, 1-9.

 

“1,3-Propanediol binds deep inside the channel to inhibit water permeation through aquaporins”. Yu, L., Rodriguez, R.A., Chen, L.,  Chen, L.Y., Perry, G., McHardy, S.F.,Yeh, C. Protein Sciences, 2016, 25, 433-441.

 

“Molecular dynamics study of human carbonic anhydrase II in complex with Zn2+ and acetazolamide on the basis of all-atom force field simulations”.  Wambo, T.O., Chen, L.Y.,  McHardy, S.F.,  Tsin, A.T. Biophysical Chemistry, 2016, 214-215, 54-60.

 

“A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance”, Pierce,  C.G., Chaturvedi, A.K., Lazzell, A.L., Powell, A.T., Saville, S.P., McHardy, S.F., Lopez-Ribot, J.L. NPJ Biofilms and Microbiomes, 2015, 15012.

 

“Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase”,  McHardy, S.F., Bohmann, H.A., Corbett, M.R., Campos, B., Tidwell, M.W., Thompson, P.M., Bemben, C.J., Menchaca, T.A., Reeves, T.E., Cantrell, W.R., Bauta, W.E., Lopez, A., Maxwell, D.M., Brecht, K.M., Sweeney, R.E., McDonough, J. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 1711-1714.

 

“18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically-engineered rhabdomyosarcoma models”,  Soundararajan, A., Abraham, J., Nelon, L.D., Prajapati, S.I., Zarzabal, L.A., Michael, J.E., McHardy, S.F., Hawkins, D.S., Malempati, S., Keller, C. Pediatric Blood & Cancer, 2012, 59(3), 485-92.