McHardy Group/CIDD Publications

“Small molecule nicotinamide N-methyltransferase inhibitors activate senescent muscle stem cells and improve regenerative capacity of aged skeletal muscle”,  Stanley Watowich, Harshini Neelakantan, Camille R Brightwell, Ted G Graber, Rosario Maroto, Hua-Yu L Wang, Stanton F McHardy, John Papaconstantinou, Christopher S Fry, Biochemical Pharmacology2019, ahead of print.

 

“The Novel Capsazepine Analog, CIDD-99, Significantly Inhibits Oral Squamous Cell Carcinoma In Vivo Through a TRPV1-Independent Induction of ER Stress, Mitochondrial Dysfunction, and Apoptosis”, Jorge De La Chapa, Prajjal Singha, Kristen Self, McKay Sallaway, Stanton F. McHardy, Matthew Hart, H. Stan McGuff, Matthew Valdez, Francisco Ruiz III, Keith Gonzales, Wes Mitchell, Srikanth R. Polusani, and Cara B. Gonzales, Journal of Oral Pathology and Medicine2019, In Press.

 

“Structure Activity Relationships for Capsazepine Analogs that Induce Mitochondrial Dysfunction and S-Phase Accumulation in OSCC”, Kristen Self, Jorge J. De La Chapa, Matthew Valdez, Francisco Ruiz III, Wes Mitchell, Stanton F. McHardy, Matthew Hart, and Cara B. Gonzales, Bioorganic & Medicinal Chemistry201927, 208-215.

 

“Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Anti-Schistosomal Agents”, Stacey Stahl, Reid Tarpley, Ambrosio Lopez, Travis Menard, Meghan A. Guzman, Alexander B. Taylor, Xiaohang Cao, Frédéric D. Chevalier, Timothy J. C. Anderson, P. John Hart, Philip T LoVerde and Stanton F. McHardy, ACS Med. Chem. Letters, 20189, 967-973 (Editor selected as featured letter and highlighted on the journal cover).

 

“Synthesis and Characterization of Pyridine Compounds for Amperometric Measurements of Leukocyte Esterase”, Douglas Hanson, Travis Menard, Teresa Shoemake, Stanton F. McHardy, Waldemar Gorski, Chembiochem, 201819, 1488-1491.

 

“Selective and Membrane-permeable Small Molecule Inhibitor of Nicotinamide N-Methyltransferase Reverses High Fat Diet-Induced Obesity in Mice”, Harshini Neelakantan, Virginia Vance, Michael Wetzel, Hua-Yu Leo Wang, Stanton F. McHardy, Celeste Finnerty, Jonathan D. Hommel, Stanley J. Watowich, Biochemical Pharmacology, 2018, 147, 141-152.

 

“Novel Small Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice”, Angelo Blasio, Dan Wang, Jingyi Wang, Florence P. Varodayan, Jacklyn Miller, Anna M. Lee, Thomas McMahon, Matthew B. Pomrenze, Sandeep Gyawali, Hua-Yu Wang, Marisa Roberto, Stanton McHardy, Michael A. Pleiss, Robert O. Messing, Biological Psychiatry201884, 193-201.

 

“Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation”, Jesus A. Romo, Ashok K. Chaturvedi, Anna L. Lazzell. Stephen P. Saville, Jose L. Lopez-Ribot, Christopher G. Pierce, Stanton F. McHardy, mBio2017, 8(6).

 

“Structure Activity Relationship Studies of New Cytotoxic Oxazoles with Selectivity for Androgen Receptor-Positive Breast Cancer Cells”, Andrew J. Robles, Shelby McCowen, Shengxin Cai, Robert H. Cichewicz, Susan L. Mooberry and Stanton F. McHardy,  J. Med. Chem.201760, 9275-9289.

 

“Electrochemical Substrate and Assay for Esterolytic Activity of Human White Blood Cells”, Douglas Hanson, Travis Menard, Stanton F. McHardy, Andrew Fleischman, Waldemar Gorski, Analytical Chemistry201789, 7781-7787.

 

“Structural and Enzymatic Insights into Species-specific Resistance to Schistosome Parasite Drug Therapy”, Alexander B. Taylor, Xiaohang Cao, Nathaniel Clark, Stephen P. Holloway, Philip T. LoVerde, Paul F. Fitzpatrick, John P. Hart, Kenneth M. Roberts, Enrica Donati, Chiara M. Polcaro, Livia Pica-Mattoccia, Donato Cioli, Reid S. Tarpley, Stanton F. McHardy, J. Biol. Chem., 2017292, 11154-11164. (Paper highlighted on journal cover)

 

“Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase”, Harshini Neelakantan, Hua-Yu Wang, Virginia Vance, Jonathan D. Hommel, Stanton F. McHardy, Stanley J. Watowich, J. Med. Chem., 201760, 5015-5028.

 

“Noncoupled Fluorescent Assay for Direct Real-Time Monitoring of Nicotinamide N-Methyltransferase Activity”, Harshini Neelakantan, Virginia Vance, Hua-Yu Leo Wang, Stanton F. McHardy and Stanley J. Watowich, Biochemistry201756, 824-832.

 

“Targeting Candida albicans filamentation for antifungal drug development”, Taissa Vila, Jesus A Romo, Stephen P. Saville, Jose L. Lopez-Ribot, Christopher G. Pierce and Stanton F. McHardy, Virulence20178, 150-158.

 

“Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015)”, Stanton F. McHardy, Hua-Yu Wang, Shelby McCowen and Mathew Valdez, Expert Opinion On Therapeutic Patents2016, 1354-3776.

 

“Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer”, Bin Yuan, Long Cheng, Qinong Ye, Kshama Gupta, Huai-Chin Chiang, Yanfen Hu, Rong Li, Harshita B. Gupta, Kate Lathrop, Richard Elledge, Tyler J. Curiel, Gangadhara R. Sareddy, Ratna Vadlamudi, Degeng Wang, Pei Wang and Stanton F. McHardy, Oncotarget, 2016, 42585-42597.

 

“Targeting Candida albicans filamentation for antifungal drug development”, Taissa Vila, Jesus A Romo, Stephen P. Saville, Jose L. Lopez-Ribot, Christopher G. Pierce and Stanton F. McHardy, Virulence, 2016, 1-9.

 

“1,3-Propanediol Binds Deep inside the Channel to Inhibit Water Permeation through Aquaporins”, Lili Yu, Roberto A. Rodriguez, L. Laurie Chen, Liao Y. Chen, George Perry, Stanton F. McHardy and Chih-ko Yeh, Protein Sciences, 2016, 25, 433-441.

 

“Molecular dynamics study of human carbonic anhydrase II in complex with Zn2+ and acetazolamide on the basis of all-atom force field simulations”, Thierry O. Wambo, Liao Y. Chen, Stanton F. McHardy and Andrew T. Tsin, Biophysical Chemistry, 2016, 214-215, 54-60.

 

“A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance”, Christopher G Pierce, Ashok K Chaturvedi, Anna L Lazzell, Alexander T Powell, Stephen P Saville, Stanton F McHardy and Jose L Lopez-Ribot. NPJ Biofilms and Microbiomes, 2015, 15012.

 

“Design, Synthesis, and Characterization of Novel, Nonquaternary Reactivators of GF-Inhibited Human Acetylcholinesterase”, Stanton F. McHardy, Jonathan A Bohmann, Michael R Corbett, Bismarck Campos, Michael W Tidwell, Paul M Thompson, Chris J Bemben, Tony A Menchaca, Tony E Reeves, William R Cantrell, Jr, William E Bauta, Ambrosio Lopez, Donald M Maxwell, Karen M Brecht, Richard E Sweeney, John McDonough, Bioorganic & Medicinal Chemistry Letters, 2014, 24, 1711-1714.

 

“18F-FDG MicroPET Imaging Detects Early Transient Response to an IGF1R Inhibitor in Genetically-Engineered Rhabdomyosarcoma Models”, Anuradha Soundararajan, Jinu Abraham, Laura D. Nelon, Suresh I. Prajapati, Lee A Zarzabal, Joel E. Michael, Stanton F. McHardy, Douglas S. Hawkins, Suman Malempati, Charles Keller, Pediatric Blood & Cancer, 2012, 59(3), 485-92.